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CS-W001157 4
Total: USD 88.00

4,4'-Difluoro-2,2'-bipyridine

  • CAS No. 1189458-67-0

  • Cat. No. CS-0160931
  • Purity≥98%
  • MDL No.MFCD11042493
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4,4'-Difluoro-2,2'-bipyridine|CS-0160931

Structure of 1189458-67-0

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Description

4,4'-Difluoro-2,2'-bipyridine features a rigid bidentate scaffold with fluorine substituents that enhance electron deficiency and improve solubility in polar solvents. This configuration enables efficient coordination to transition metals in catalytic systems, particularly in photoredox and cross-coupling applications. The molecule exhibits bench-stable handling under standard conditions and integrates readily into complex ligand architectures.

Application

4,4'-Difluoro-2,2'-bipyridine serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl architectures under palladium- or nickel-mediated conditions. The difluorinated substitution pattern enhances both electronic modulation and metabolic stability in target scaffolds, while the bipyridyl core provides strong chelation for metal complexes. Bench-stable and readily purified by column chromatography, it functions effectively in standard synthetic workflows for pharmaceutical and materials chemistry applications.

General Information

  • CAS No. 1189458-67-0
  • Cat. No. CS-0160931
  • Purity ≥98%
  • MDL No. MFCD11042493
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆F₂N₂
  • Molecular Weight 192.17
  • Synonym(s) None
  • SMILES FC=1C=CN=C(C1)C=2N=CC=C(F)C2

Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.4218
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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