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Structure of 1190862-72-6
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5-Bromo-6-methylnicotinic acid features a bromine substituent at the 5-position and a methyl group at the 6-position of the nicotinic acid scaffold. This electron-deficient heterocycle integrates readily into synthetic routes requiring steric and electronic modulation, offering enhanced stability under standard conditions.
5-Bromo-6-methylnicotinic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 3-position via palladium-catalyzed cross-coupling. The bromine substituent provides high reactivity in Suzuki, Stille, and Negishi reactions, while the methyl group enhances metabolic stability and lipophilicity. Bench-stable and readily purified by recrystallization, it functions effectively in the synthesis of heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: