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CS-W001157 4
Total: USD 88.00

4-Bromo-1-cyclopropylpyridin-2(1H)-one

  • CAS No. 1193334-86-9

  • Cat. No. CS-0054503
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Bromo-1-cyclopropylpyridin-2(1H)-one|CS-0054503

Structure of 1193334-86-9

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Description

4-Bromo-1-cyclopropylpyridin-2(1H)-one features a brominated pyridinone core paired with a cyclopropyl substituent, delivering enhanced metabolic stability and tunable electronic properties. This scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds, offering improved solubility and compatibility with transition-metal-catalyzed coupling reactions under standard conditions.

Application

4-Bromo-1-cyclopropylpyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo substituent. The cyclopropyl group enhances metabolic stability and modulates electronic properties, while the pyridin-2-one core provides a hydrogen-bonding scaffold for target engagement. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of bioactive heterocycles and API intermediates.

General Information

  • CAS No. 1193334-86-9
  • Cat. No. CS-0054503
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrNO
  • Molecular Weight 214.06
  • Synonym(s) 4-Bromo-1-cyclopropylpyridin-2-one
  • SMILES O=C1C=C(Br)C=CN1C2CC2

Computational Chemistry Data

  • TPSA   22
  • LogP   1.9457
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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