2-Chloro-5-fluoropyridin-4-ol

Name: 2-Chloro-5-fluoropyridin-4-ol
Brand: ChemScene
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CAS No. 1196153-96-4
Cat. No. CS-0104843
Purity≥98%
MDL No.MFCD13189882

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-fluoropyridin-4-ol|CS-0104843

Structure of 1196153-96-4

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General Information

CAS No. 1196153-96-4
Cat. No. CS-0104843
Purity ≥98%
MDL No. MFCD13189882
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃ClFNO
Molecular Weight 147.53
Synonym(s) 2-chloro-5-fluoro-4-Pyridinol
SMILES OC1=CC(Cl)=NC=C1F

Description

2-Chloro-5-fluoropyridin-4-ol features a pyridin-4-ol core with orthogonal halogen substituents at C2 and C5, enabling selective functionalization in late-stage diversification. The electron-deficient ring system facilitates nucleophilic substitution, while the phenolic OH group offers a handle for derivatization under mild conditions. This scaffold exhibits enhanced stability and solubility in polar solvents, streamlining integration into complex synthetic sequences.

Application

2-Chloro-5-fluoropyridin-4-ol serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The ortho-halogen and phenolic hydroxyl groups facilitate selective derivatization, while the fluorine substituent enhances metabolic stability and modulates electronic properties. Bench-stable and compatible with common protecting group strategies, it functions reliably in the synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 33.12
LogP 1.5797
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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2-Chloro-5-fluoropyridin-4-ol

CAS No. 1196153-96-4

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