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CS-W001157 4
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4-Fluoro-3-morpholinobenzaldehyde

  • CAS No. 1197193-13-7

  • Cat. No. CS-0044897
  • Molecule weight209.22
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-3-morpholinobenzaldehyde|CS-0044897

Structure of 1197193-13-7

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General Information

  • CAS No. 1197193-13-7
  • Cat. No. CS-0044897
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂FNO₂
  • Molecular Weight 209.22
  • Synonym(s) 4-fluoro-3-(morpholin-4-yl)benzaldehyde
  • SMILES O=CC1=CC=C(F)C(N2CCOCC2)=C1

Description

4-Fluoro-3-morpholinobenzaldehyde features a morpholine ring appended to a fluorinated benzaldehyde core, delivering enhanced solubility and electron-rich character. This combination enables efficient coupling in Suzuki and Buchwald-Hartwig reactions, serving as a robust scaffold for bioactive molecule synthesis under standard conditions.

Application

4-Fluoro-3-morpholinobenzaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its orthogonal functionalization profile—combining a reactive aldehyde with a fluorinated aromatic ring and a morpholine moiety—facilitates diverse transformations including reductive amination, Suzuki coupling, and nucleophilic addition. The compound exhibits good bench stability and ease of purification, supporting its use in multi-step synthesis and high-throughput screening campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   1.4748
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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