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Structure of 120-66-1
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N-(o-Tolyl)acetamide features a benzene ring substituted with both a methyl and acetamide group in ortho orientation, creating a sterically constrained, electron-rich aromatic system. This configuration enhances solubility in organic solvents while maintaining bench stability. The compound serves as a key scaffold in medicinal chemistry for designing kinase inhibitors and bioactive heterocycles due to its ability to integrate into diverse molecular frameworks under standard conditions.
N-(o-Tolyl)acetamide serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted anilines and heterocyclic scaffolds. Its ortho-tolyl group provides steric and electronic modulation, while the acetamide functionality offers stability and compatibility with standard transformations such as reduction, coupling, and electrophilic substitution. The compound exhibits excellent bench stability, ease of purification, and broad functional group tolerance, making it well-suited for iterative synthesis workflows and API intermediate development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H318
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Precautionary Statements : P264-P270-P280-P305+P351+P338-P330-P501
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Lot numbers can be found on the outside label of a product: