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Structure of 120136-28-9
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4-Ethynyl-2-fluoro-1-methoxybenzene features a trifunctional aromatic core integrating an ethynyl group, a fluorine atom, and a methoxy substituent. This electron-deficient scaffold enables efficient coupling in palladium-catalyzed reactions, offering high stability under standard conditions. The strategic placement of the ethynyl moiety facilitates direct incorporation into complex molecular architectures.
4-Ethynyl-2-fluoro-1-methoxybenzene serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated aryl systems. The ethynyl group facilitates Sonogashira and Glaser-type couplings, while the fluorine and methoxy substituents provide orthogonal reactivity and enhanced metabolic stability. This compound exhibits excellent bench stability and is compatible with standard purification protocols, making it ideal for iterative synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: