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CS-W001157 4
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Methyl 4-bromo-6-chloropyridine-2-carboxylate

  • CAS No. 1206249-86-6

  • Cat. No. CS-0214754
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 4-bromo-6-chloropyridine-2-carboxylate|CS-0214754

Structure of 1206249-86-6

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General Information

  • CAS No. 1206249-86-6
  • Cat. No. CS-0214754
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrClNO₂
  • Molecular Weight 250.48
  • Synonym(s) Methyl 4-bromo-6-chloropicolinate
  • SMILES COC(=O)C1=NC(=CC(=C1)Br)Cl

Description

Methyl 4-bromo-6-chloropyridine-2-carboxylate features a pyridine core bearing bromo and chloro substituents at the 4- and 6-positions, respectively, with a methyl ester group at C2. This electron-deficient heterocycle integrates readily into cross-coupling reactions, serving as a key building block for functionalized pharmaceutical intermediates and agrochemical scaffolds under standard conditions.

Application

Methyl 4-bromo-6-chloropyridine-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates selective coupling under standard conditions, while the chloro and ester functionalities provide stability and compatibility with diverse reaction environments. This compound is particularly valuable for constructing substituted pyridine scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.2841
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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