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Ethyl 5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxylate hydrochloride

  • CAS No. 1207175-08-3

  • Cat. No. CS-0049449
  • Purity≥97%
  • MDL No.MFCD10566314

*For research and further manufacturing use only, not for direct human use.

Ethyl 5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxylate hydrochloride|CS-0049449

Structure of 1207175-08-3

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General Information

  • CAS No. 1207175-08-3
  • Cat. No. CS-0049449
  • Purity ≥97%
  • MDL No. MFCD10566314
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅ClN₂O₂
  • Molecular Weight 242.70
  • Synonym(s) None
  • SMILES CCOC(C1=CC2=C(N=C1)CNCC2)=O.Cl

Description

Ethyl 5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxylate hydrochloride offers a stable, moisture-tolerant platform for constructing nitrogen-rich heterocycles. The protonated naphthyridine core enhances solubility in polar solvents, facilitating efficient coupling reactions and downstream derivatization in medicinal chemistry campaigns.

Application

Ethyl 5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxylate hydrochloride serves as a versatile heterocyclic building block for medicinal chemistry and process development. The tetrahydro-1,7-naphthyridine core provides a rigid, pharmacologically relevant scaffold with enhanced solubility and stability. The ester functionality enables facile derivatization via hydrolysis, amidation, or cross-coupling reactions. The protonated nitrogen enhances crystallinity and facilitates purification, making it well-suited for scalable synthesis and solid-phase applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.22
  • LogP   1.3258
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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