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CS-W001157 4
Total: USD 88.00

6-Bromo-8-fluoroquinazolin-4-ol

  • CAS No. 1209498-47-4

  • Cat. No. CS-0308017
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-8-fluoroquinazolin-4-ol|CS-0308017

Structure of 1209498-47-4

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General Information

  • CAS No. 1209498-47-4
  • Cat. No. CS-0308017
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄BrFN₂O
  • Molecular Weight 243.03
  • Synonym(s) None
  • SMILES OC1=C2C=C(Br)C=C(F)C2=NC=N1

Description

6-Bromo-8-fluoroquinazolin-4-ol features a sterically accessible quinazoline core bearing bromo and fluoro substituents at the 6- and 8-positions, respectively. This electron-deficient scaffold integrates readily into synthetic routes requiring halogen-directed functionalization or metal-catalyzed coupling. The hydroxyl group at C4 enables direct derivatization or hydrogen bonding in target binding interactions. Bench-stable under standard conditions, it serves as a key intermediate for bioactive molecule development.

Application

6-Bromo-8-fluoroquinazolin-4-ol serves as a versatile building block for the synthesis of quinazoline-based pharmaceutical scaffolds. Its well-defined halogen and hydroxyl functionalities enable direct functionalization via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The molecule exhibits excellent bench stability and facilitates straightforward purification, making it ideal for medicinal chemistry campaigns targeting kinase inhibitors and other bioactive heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   2.237
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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