4-Bromo-2-chloro-3-fluoropyridine

Name: 4-Bromo-2-chloro-3-fluoropyridine
Brand: ChemScene
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CAS No. 1211526-56-5
Cat. No. CS-W007302
Purity≥95%
MDL No.MFCD16606306

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Bromo-2-chloro-3-fluoropyridine|CS-W007302

Structure of 1211526-56-5

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Description

4-Bromo-2-chloro-3-fluoropyridine is a halogenated pyridine derivative featuring strategically positioned bromo, chloro, and fluoro substituents. This combination enables selective functionalization in late-stage diversification of pharmaceutical intermediates. The molecule exhibits enhanced reactivity in transition metal-catalyzed cross-coupling processes due to its electron-deficient aromatic core and orthogonal halogen handles. Its bench-stable nature supports reliable handling under standard conditions.

Application

4-Bromo-2-chloro-3-fluoropyridine serves as a versatile trifunctional pyridine building block in medicinal chemistry and agrochemical synthesis. Its orthogonal halogen reactivity enables sequential cross-coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig transformations, under mild conditions. The compound exhibits excellent bench stability and facilitates efficient late-stage functionalization due to predictable regioselectivity and tolerance of diverse functional groups.

General Information

CAS No. 1211526-56-5
Cat. No. CS-W007302
Purity ≥95%
MDL No. MFCD16606306
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂BrClFN
Molecular Weight 210.43
Synonym(s) 2-chloro-3-fluoro-4-broMopyridine
SMILES FC1=C(Br)C=CN=C1Cl

Computational Chemistry Data

TPSA 12.89
LogP 2.6366
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Bromo-2-chloro-3-fluoropyridine

CAS No. 1211526-56-5

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