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CS-W001157 4
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6-Chloro-2-fluoronicotinic acid

  • CAS No. 1211578-46-9

  • Cat. No. CS-W022476
  • Purity≥97%
  • MDL No.MFCD16610397

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-fluoronicotinic acid|CS-W022476

Structure of 1211578-46-9

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General Information

  • CAS No. 1211578-46-9
  • Cat. No. CS-W022476
  • Purity ≥97%
  • MDL No. MFCD16610397
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClFNO₂
  • Molecular Weight 175.55
  • Synonym(s) 6-chloro-2-fluoropyridine-3-carboxylic acid
  • SMILES O=C(O)C1=C(F)N=C(Cl)C=C1

Description

6-Chloro-2-fluoronicotinic acid features a strategically positioned chloro and fluoro substituent on the nicotinic acid scaffold, enhancing electron-withdrawing character and enabling selective functionalization in medicinal chemistry. This bench-stable derivative integrates readily into heterocyclic synthesis pathways, offering improved solubility and reactivity under standard conditions.

Application

6-Chloro-2-fluoronicotinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-halogenated pyridine core enables direct functionalization via palladium-catalyzed cross-coupling, while the carboxylic acid group facilitates amide formation and esterification under standard conditions. The molecule exhibits excellent bench stability and compatibility with diverse reaction environments, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.5723
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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