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Structure of 1211589-63-7
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5-(tert-Butyl)nicotinic acid features a sterically hindered tert-butyl group at the pyridine ring's 5-position, enhancing metabolic stability and lipophilicity. This substitution pattern improves membrane permeability while maintaining the carboxylic acid functionality for conjugation or salt formation. The molecule exhibits robust bench stability and compatibility with standard synthetic protocols in medicinal chemistry workflows.
5-(tert-Butyl)nicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted pyridine derivatives through standard functional group transformations. Its tert-butyl substituent provides steric bulk and enhanced stability, facilitating purification and improving metabolic resistance in downstream applications. The carboxylic acid moiety allows for direct coupling reactions or derivatization into amides, esters, and other bioactive scaffolds commonly found in pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: