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CS-W001157 4
Total: USD 88.00

(R)-2-(tert-Butoxycarbonyl)isoindoline-1-carboxylic acid

  • CAS No. 1212086-74-2

  • Cat. No. CS-0468850
  • Molecule weight263.29
  • Purity≥98%
  • MDL No.MFCD27940087

*For research and further manufacturing use only, not for direct human use.

(R)-2-(tert-Butoxycarbonyl)isoindoline-1-carboxylic acid|CS-0468850

Structure of 1212086-74-2

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General Information

  • CAS No. 1212086-74-2
  • Cat. No. CS-0468850
  • Purity ≥98%
  • MDL No. MFCD27940087
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₇NO₄
  • Molecular Weight 263.29
  • Synonym(s) None
  • SMILES O=C([C@@H]1N(C(OC(C)(C)C)=O)CC2=C1C=CC=C2)O

Description

(R)-2-(tert-Butoxycarbonyl)isoindoline-1-carboxylic acid serves as a chiral building block for the synthesis of bioactive isoindoline derivatives. The tert-butoxycarbonyl group provides stable protection of the amine, enabling sequential transformations under standard conditions. This bench-stable intermediate integrates readily into peptide and heterocyclic architectures.

Application

(R)-2-(tert-Butoxycarbonyl)isoindoline-1-carboxylic acid serves as a versatile chiral building block for the synthesis of isoindoline-based pharmaceutical intermediates. Its Boc-protected amine and carboxylic acid functionalities enable orthogonal transformations, facilitating peptide coupling, cyclization, and late-stage functionalization. The compound exhibits excellent bench stability and simplifies purification in multi-step sequences, making it well-suited for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.563
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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