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Structure of 1214332-47-4
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Methyl 6-bromo-3-fluoropicolinate is a fluorinated, brominated pyridine derivative featuring complementary electrophilic handles at the 3- and 6-positions. This electron-deficient heterocycle integrates readily into cross-coupling reactions and serves as a key building block for bioactive molecule synthesis.
Methyl 6-bromo-3-fluoropicolinate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki, Stille, or Negishi couplings, while the fluorine enhances metabolic stability and modulates electronic properties in pharmaceutical scaffolds. This compound exhibits excellent bench stability and is readily purified by flash chromatography, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: