3-Chloro-5-fluoropyridin-2(1H)-one

Name: 3-Chloro-5-fluoropyridin-2(1H)-one
Brand: ChemScene
Availability: InStock
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CAS No. 1214345-43-3
Cat. No. CS-0064676
Purity≥97%
MDL No.MFCD13185439

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Chloro-5-fluoropyridin-2(1H)-one|CS-0064676

Structure of 1214345-43-3

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Description

3-Chloro-5-fluoropyridin-2(1H)-one features a fused heterocyclic core with orthogonal halogen substituents enabling precise functionalization. This bench-stable, moisture-tolerant scaffold integrates readily into synthetic routes for bioactive molecules, particularly in medicinal chemistry and agrochemical development.

Application

3-Chloro-5-fluoropyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its orthogonal reactivity allows selective functionalization at the C3 chlorine and C5 fluorine positions, facilitating Suzuki-Miyaura, Buchwald-Hartwig, and nucleophilic substitution reactions. The compound exhibits excellent bench stability and compatibility with common protecting group strategies, making it ideal for multi-step synthesis of API candidates and kinase inhibitor frameworks.

General Information

CAS No. 1214345-43-3
Cat. No. CS-0064676
Purity ≥97%
MDL No. MFCD13185439
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃ClFNO
Molecular Weight 147.53
Synonym(s) 3-Chloro-5-fluoro-2-hydroxypyridine
SMILES O=C1C(Cl)=CC(F)=CN1

Computational Chemistry Data

TPSA 32.86
LogP 1.1674
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Chloro-5-fluoropyridin-2(1H)-one

CAS No. 1214345-43-3

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