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Structure of 1215205-35-8
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3-Bromo-1-methyl-5-(trifluoromethyl)pyridin-2(1H)-one features a trifluoromethyl group enhancing electron-withdrawal and metabolic stability, while the bromo substituent enables facile cross-coupling reactions. The pyridinone core provides a rigid, polar scaffold suitable for medicinal chemistry applications. This bench-stable compound integrates efficiently into diverse synthetic pathways.
3-Bromo-1-methyl-5-(trifluoromethyl)pyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the trifluoromethyl and carbonyl functionalities enhance metabolic stability and modulate electronic properties. Bench-stable and readily purified by flash chromatography, it functions as a key intermediate in the synthesis of bioactive heterocycles and targeted therapeutics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: