Methyl 2-(2-chloropyrimidin-4-yl)acetate

Name: Methyl 2-(2-chloropyrimidin-4-yl)acetate
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CAS No. 1216129-71-3
Cat. No. CS-0214712
Purity≥97%
MDL No.None

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Methyl 2-(2-chloropyrimidin-4-yl)acetate|CS-0214712

Structure of 1216129-71-3

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Description

Methyl 2-(2-chloropyrimidin-4-yl)acetate features a pyrimidine core functionalized with a chloro group at C2 and an acetyl ester side chain, enabling direct integration into pharmaceutical intermediates. The electron-deficient pyrimidine ring enhances reactivity in nucleophilic substitution cascades, while the methyl ester serves as a stable handle for subsequent transformations under standard conditions.

Application

Methyl 2-(2-chloropyrimidin-4-yl)acetate serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds. The chloropyrimidine moiety facilitates nucleophilic substitution reactions, while the ester group supports subsequent transformations including hydrolysis, reduction, or coupling protocols. This compound exhibits good bench stability and is compatible with standard reaction conditions, making it well-suited for modular synthesis of bioactive heterocycles and API intermediates.

General Information

CAS No. 1216129-71-3
Cat. No. CS-0214712
Purity ≥97%
MDL No. None
Storage 4°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇ClN₂O₂
Molecular Weight 186.60
Synonym(s) 4-Pyrimidineacetic acid, 2-chloro-, methyl ester
SMILES COC(=O)CC1=NC(=NC=C1)Cl

Computational Chemistry Data

TPSA 52.08
LogP 0.8455
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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Methyl 2-(2-chloropyrimidin-4-yl)acetate

CAS No. 1216129-71-3

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