(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)hexanoic acid

Name: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)hexanoic acid
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CAS No. 1217482-47-7
Cat. No. CS-0068568
Purity≥97%
MDL No.None

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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)hexanoic acid|CS-0068568

Structure of 1217482-47-7

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General Information

CAS No. 1217482-47-7
Cat. No. CS-0068568
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₂H₂₅NO₄
Molecular Weight 367.44
Synonym(s) FMoc-N-Methyl-D-norleucine
SMILES CCCC[C@H](C(O)=O)N(C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C

Description

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)hexanoic acid features a chiral, bench-stable amino acid derivative with a fluorenylmethoxycarbonyl (Fmoc) protecting group. This configuration enables direct incorporation into peptide synthesis workflows, where the methylated amine prevents undesired side reactions while maintaining compatibility with standard coupling conditions.

Application

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)hexanoic acid serves as a valuable chiral building block in peptide synthesis, enabling efficient Nα-alkylation and side-chain functionalization. The Fmoc-methylamino handle provides excellent stability and orthogonal deprotection compatibility, while the (R)-configured hexanoic acid backbone supports diverse coupling reactions. Its bench-stable nature and clean purification profile facilitate scalable synthesis of complex peptidomimetics and bioactive scaffolds.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 66.84
LogP 4.5107
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 7

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Leucine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)hexanoic acid

CAS No. 1217482-47-7

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