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CS-W001157 4
Total: USD 88.00

2-(4-Cyclopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 1219741-94-2

  • Cat. No. CS-0042402
  • Purity≥97%
  • MDL No.MFCD10698529

*For research and further manufacturing use only, not for direct human use.

2-(4-Cyclopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0042402

Structure of 1219741-94-2

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General Information

  • CAS No. 1219741-94-2
  • Cat. No. CS-0042402
  • Purity ≥97%
  • MDL No. MFCD10698529
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₁BO₂
  • Molecular Weight None
  • Synonym(s) 4-(Cyclopropyl)phenylboronic acid pinacol ester
  • SMILES CC1(C)C(C)(C)OB(C2=CC=C(C3CC3)C=C2)O1

Description

This boronate ester features a cyclopropyl-substituted aryl group, enabling efficient cross-coupling in Suzuki-Miyaura reactions. The tetramethyl-substituted dioxaborolane ring enhances stability and shelf life under standard conditions. Ideal for constructing biaryl architectures in medicinal chemistry and materials synthesis.

Application

2-(4-Cyclopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boron building block for Suzuki-Miyaura cross-coupling reactions. Its cyclopropyl-substituted aryl group enables efficient incorporation into biaryl scaffolds common in pharmaceutical and agrochemical development. The tetramethyl-substituted dioxaborolane moiety offers enhanced stability, mild reaction conditions, and compatibility with diverse functional groups, facilitating reliable coupling across standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.8632
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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