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CS-W001157 4
Total: USD 88.00

1,3-Bis(4-chlorophenyl)thiourea

  • CAS No. 1220-00-4

  • Cat. No. CS-0182195
  • Purity≥98%
  • MDL No.MFCD00275761

*For research and further manufacturing use only, not for direct human use.

1,3-Bis(4-chlorophenyl)thiourea|CS-0182195

Structure of 1220-00-4

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General Information

  • CAS No. 1220-00-4
  • Cat. No. CS-0182195
  • Purity ≥98%
  • MDL No. MFCD00275761
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀Cl₂N₂S
  • Molecular Weight 297.20
  • Synonym(s) Thiourea,N,N'-bis(4-chlorophenyl)-
  • SMILES S=C(NC1=CC=C(C=C1)Cl)NC2=CC=C(C=C2)Cl

Description

1,3-Bis(4-chlorophenyl)thiourea features two electron-deficient 4-chlorophenyl groups flanking a central thiourea core, enabling strong hydrogen-bonding interactions. This rigid, planar structure enhances crystallinity and thermal stability, making it suitable for coordination chemistry and solid-state studies.

Application

1,3-Bis(4-chlorophenyl)thiourea serves as a versatile building block in medicinal chemistry and materials science, enabling the synthesis of heterocyclic scaffolds through controlled condensation reactions. Its dual aryl-thiourea functionality provides excellent stability under standard reaction conditions, facilitates purification via recrystallization, and offers predictable reactivity in transition metal-catalyzed couplings and cyclization processes.

Synthesis

  • Route1
    • null|null
      75-15-0
    • null|null
      106-47-8
    • ~94%
    • In-stock
      1,3-Bis(4-chlorophenyl)thiourea|CS-0182195
      1220-00-4

    References

    • Anary-Abbasinejad, Mohammad; Karimi, Nadia; Mehrabi, Hossein; Ranjbar-Karimi, Reza Journal of Sulfur Chemistry, 2012 , vol. 33, # 6 p. 653 - 659
  • Route2
    • null|null
      534-18-9
    • null|null
      106-47-8
    • ~89%
    • null|null
      2044-27-1
    • In-stock
      1,3-Bis(4-chlorophenyl)thiourea|CS-0182195
      1220-00-4

    References

    • Takikawa, Yuji; Inoue, Noriyuki; Sato, Ryu; Takizawa, Saburo Chemistry Letters, 1982 , p. 641 - 642
  • Route3
    • null|null
      106-47-8
    • null|null
      2131-55-7
    • ~92%
    • In-stock
      1,3-Bis(4-chlorophenyl)thiourea|CS-0182195
      1220-00-4

    References

    • Li; Wang; Luo Synthetic Communications, 2001 , vol. 31, # 5 p. 781 - 785

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06,GHS09
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335-H410
Precautionary Statements : P261-P273-P280-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.06
  • LogP   4.8023
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   2

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