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Structure of 1220219-14-6
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5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzonitrile features a boronate ester group paired with an electron-deficient trifluoromethyl nitrile moiety. This combination enables efficient Suzuki-Miyaura coupling under standard conditions, delivering arylated products with high functional group tolerance and excellent stability during storage and handling.
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzonitrile serves as a versatile boronate building block in palladium-catalyzed cross-coupling reactions. The tetramethylboronate group enables efficient Suzuki-Miyaura coupling under mild conditions, while the trifluoromethyl and nitrile functionalities provide enhanced metabolic stability and electronic modulation. Bench-stable and readily purified by flash chromatography, it facilitates the construction of complex biaryl scaffolds common in medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319
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Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: