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CS-W001157 4
Total: USD 88.00

1H-1,2,4-Triazol-5-ol

  • CAS No. 122333-32-8

  • Cat. No. CS-0166923
  • Purity≥98%
  • MDL No.MFCD18807024

*For research and further manufacturing use only, not for direct human use.

1H-1,2,4-Triazol-5-ol|CS-0166923

Structure of 122333-32-8

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General Information

  • CAS No. 122333-32-8
  • Cat. No. CS-0166923
  • Purity ≥98%
  • MDL No. MFCD18807024
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₃N₃O
  • Molecular Weight 85.06
  • Synonym(s) 1H-1,2,4-Triazol-5-ol(9CI)
  • SMILES OC1=NC=NN1

Description

1H-1,2,4-Triazol-5-ol features a polar, hydrogen-bonding heterocyclic core that enhances solubility in aqueous and protic solvents. This bench-stable compound serves as a key scaffold in bioactive molecule design, integrating readily into pharmaceutical intermediates through nucleophilic substitution or coupling reactions.

Application

1H-1,2,4-Triazol-5-ol serves as a versatile heterocyclic building block in medicinal chemistry and materials science. Its hydroxyl group enables direct derivatization and hydrogen bonding interactions, while the triazole core provides metabolic stability and favorable solubility. The compound exhibits bench stability, facilitates modular synthesis of bioactive scaffolds, and functions effectively in standard coupling and functionalization protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   61.8
  • LogP   -0.4897
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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