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Structure of 1227502-35-3
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5-Bromo-3-(hydroxymethyl)pyridin-2(1H)-one features a pyridinone core functionalized with a bromine at C5 and a hydroxymethyl group at C3, enabling direct derivatization via nucleophilic substitution or oxidation. The hydroxymethyl moiety offers a handle for further modification, while the electron-deficient pyridinone ring enhances reactivity in cross-coupling processes. This scaffold exhibits stability under standard conditions and compatibility with diverse reaction environments.
5-Bromo-3-(hydroxymethyl)pyridin-2(1H)-one serves as a versatile building block for the synthesis of bioactive heterocycles, enabling efficient functionalization at both the bromo and hydroxymethyl positions. Its stability under standard reaction conditions facilitates coupling with arylboranes, palladium-catalyzed cross-couplings, and derivatization via oxidation or protection of the hydroxymethyl group. This compound functions effectively in medicinal chemistry campaigns requiring pyridone scaffolds with orthogonal reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: