2-Chloro-5-hydroxy-4-methylpyridine

Name: 2-Chloro-5-hydroxy-4-methylpyridine
Brand: ChemScene
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CAS No. 1227502-89-7
Cat. No. CS-0195236
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-hydroxy-4-methylpyridine|CS-0195236

Structure of 1227502-89-7

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Description

2-Chloro-5-hydroxy-4-methylpyridine features a reactive chloro group flanked by a hydroxyl and methyl substituent on the pyridine ring, enabling selective functionalization in synthetic pathways. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds and serves as a key intermediate in agrochemical and pharmaceutical development under standard conditions.

Application

2-Chloro-5-hydroxy-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds. The hydroxyl group facilitates direct derivatization or protection, while the chloro and methyl substituents provide orthogonal reactivity for cross-coupling and functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for modular synthesis workflows in API development.

General Information

CAS No. 1227502-89-7
Cat. No. CS-0195236
Purity ≥97%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆ClNO
Molecular Weight 143.57
Synonym(s) 6-Chloro-4-methylpyridin-3-ol
SMILES CC1=CC(=NC=C1O)Cl

Computational Chemistry Data

TPSA 33.12
LogP 1.74902
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-hydroxy-4-methylpyridine

CAS No. 1227502-89-7

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