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Structure of 1227579-04-5
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2,3-Difluoro-6-methylpyridine offers a strategically positioned trifluoromethyl-like electronic profile with enhanced stability. The ortho-fluorine substituents deliver strong electron-withdrawing effects, while the methyl group at C6 provides steric and electronic modulation. This combination enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive heterocycles.
2,3-Difluoro-6-methylpyridine serves as a versatile building block in medicinal chemistry, enabling site-selective functionalization via directed ortho-metalation. Its fluorinated pyridine core provides enhanced metabolic stability and modulates electronic properties for drug candidates. The methyl group offers a handle for further derivatization, while the difluoro substitution pattern enhances lipophilicity and membrane permeability. This compound exhibits bench stability and compatibility with standard cross-coupling protocols, facilitating integration into complex molecular architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: