Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2,3-Difluoro-6-methylpyridine

  • CAS No. 1227579-04-5

  • Cat. No. CS-0443059
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,3-Difluoro-6-methylpyridine|CS-0443059

Structure of 1227579-04-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

Description

2,3-Difluoro-6-methylpyridine offers a strategically positioned trifluoromethyl-like electronic profile with enhanced stability. The ortho-fluorine substituents deliver strong electron-withdrawing effects, while the methyl group at C6 provides steric and electronic modulation. This combination enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive heterocycles.

Application

2,3-Difluoro-6-methylpyridine serves as a versatile building block in medicinal chemistry, enabling site-selective functionalization via directed ortho-metalation. Its fluorinated pyridine core provides enhanced metabolic stability and modulates electronic properties for drug candidates. The methyl group offers a handle for further derivatization, while the difluoro substitution pattern enhances lipophilicity and membrane permeability. This compound exhibits bench stability and compatibility with standard cross-coupling protocols, facilitating integration into complex molecular architectures.

General Information

  • CAS No. 1227579-04-5
  • Cat. No. CS-0443059
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅F₂N
  • Molecular Weight 129.11
  • Synonym(s) 2,3-difluoro-6-methyl-pyridine
  • SMILES CC1=NC(=C(C=C1)F)F

Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.66822
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2,3-Difluoro-6-methylpyridine sigma2,3-Difluoro-6-methylpyridine manufacturer2,3-Difluoro-6-methylpyridine price2,3-Difluoro-6-methylpyridine structure2,3-Difluoro-6-methylpyridine SDSbuy 2,3-Difluoro-6-methylpyridine2,3-Difluoro-6-methylpyridine supplier2,3-Difluoro-6-methylpyridine uses2,3-Difluoro-6-methylpyridine molecular weightprice of 2,3-Difluoro-6-methylpyridine2,3-Difluoro-6-methylpyridine chemical name formula of 2,3-Difluoro-6-methylpyridine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label