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CS-W001157 4
Total: USD 88.00

Tert-butyl 4-(but-3-yn-1-yl)piperazine-1-carboxylate

  • CAS No. 1232152-74-7

  • Cat. No. CS-0456468
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Tert-butyl 4-(but-3-yn-1-yl)piperazine-1-carboxylate|CS-0456468

Structure of 1232152-74-7

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Description

Tert-butyl 4-(but-3-yn-1-yl)piperazine-1-carboxylate features a terminal alkyne group appended to a piperazine scaffold, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation. The tert-butyl ester provides stability and ease of deprotection under mild acidic conditions, while the piperazine moiety offers favorable solubility and metabolic resilience. This reagent serves as a robust building block in click chemistry workflows.

Application

Tert-butyl 4-(but-3-yn-1-yl)piperazine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperazine-based scaffolds via copper-catalyzed azide-alkyne cycloaddition (CuAAC). The terminal alkyne functionality facilitates conjugation with azides under mild conditions, while the tert-butyl carbamate group offers excellent stability and convenient deprotection. Its robustness and compatibility with diverse functional groups make it ideal for late-stage diversification in API development.

General Information

  • CAS No. 1232152-74-7
  • Cat. No. CS-0456468
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₂N₂O₂
  • Molecular Weight 238.33
  • Synonym(s) None
  • SMILES C#CCCN1CCN(CC1)C(=O)OC(C)(C)C

Computational Chemistry Data

  • TPSA   32.78
  • LogP   1.5624
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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