tert-Butyl 4-methylpiperidine-1-carboxylate

Name: tert-Butyl 4-methylpiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 123387-50-8
Cat. No. CS-0069646
Purity≥97%
MDL No.MFCD04114947

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-methylpiperidine-1-carboxylate|CS-0069646

Structure of 123387-50-8

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 123387-50-8
Cat. No. CS-0069646
Purity ≥97%
MDL No. MFCD04114947
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₁NO₂
Molecular Weight 199.29
Synonym(s) 1-Boc-4-Methylpiperidine
SMILES O=C(N1CCC(C)CC1)OC(C)(C)C

Description

tert-Butyl 4-methylpiperidine-1-carboxylate serves as a protected piperidine scaffold with enhanced stability and solubility. The tert-butyl carbamate group enables convenient deprotection under mild acidic conditions, while the 4-methyl substitution provides steric shielding and modulates basicity. This derivative integrates readily into medicinal chemistry libraries for targeted optimization of pharmacokinetic properties.

Application

tert-Butyl 4-methylpiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. The tert-butyl carbamate group provides excellent bench stability and facile deprotection under mild acidic conditions, while the 4-methyl substitution enhances conformational rigidity and modulates basicity. It functions reliably in reductive amination, alkylation, and transition-metal-catalyzed coupling reactions, supporting diverse functionalization strategies for drug discovery applications.

Synthesis

Route1
- 626-58-4
- In-stock
  
  24424-99-5
- ~99%
- In-stock
  
  123387-50-8
References
- Cossy, Janine; Belotti, Damien Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 15 p. 1989 - 1992
Route2
- In-stock
  
  24424-99-5
- 544478-11-7
- ~86%
- In-stock
  
  123387-50-8
References
- Chandrasekhar; Babu, B. Nagendra; Reddy, Ch. Raji Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2057 - 2059
Route3
- In-stock
  
  159635-49-1
- ~%
- In-stock
  
  123387-50-8
References
- EP2565192 A1, ; Paragraph 0533 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06,GHS09
Signal Word : Danger	UN#: 2810
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H227-H301-H315-H319-H335-H410
Precautionary Statements : P210-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P370+P378-P391-P403-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 29.54
LogP 2.6534
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

123387-50-8 sigma123387-50-8 manufacturer123387-50-8 price123387-50-8 structure123387-50-8 SDSbuy 123387-50-8123387-50-8 supplier123387-50-8 uses123387-50-8 molecular weightprice of 123387-50-8123387-50-8 chemical name formula of 123387-50-8

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

tert-Butyl 4-methylpiperidine-1-carboxylate

CAS No. 123387-50-8

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words