Boc-Trp(6-Cl)-OH

Name: Boc-Trp(6-Cl)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 1234875-52-5
Cat. No. CS-0439453
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Boc-Trp(6-Cl)-OH is a protected tryptophan derivative featuring a chlorine atom at the 6-position of the indole ring. This electron-deficient substitution enhances stability and modulates reactivity in peptide synthesis. The Boc group provides convenient protection for N-terminal amine handling, enabling efficient coupling under standard conditions.

Application

Boc-Trp(6-Cl)-OH serves as a protected tryptophan building block for peptide synthesis, featuring a chlorine substituent at the 6-position of the indole ring. The Boc group provides stable protection under standard acidic conditions, enabling selective deprotection during sequential coupling. Its functional group tolerance facilitates incorporation into complex peptide scaffolds and heterocyclic systems, while the electron-withdrawing chlorine enhances metabolic stability in bioactive sequences. Ideal for solid-phase and solution-phase synthesis workflows.

General Information

CAS No. 1234875-52-5
Cat. No. CS-0439453
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₁₉ClN₂O₄
Molecular Weight 338.79
Synonym(s) L-N-Boc-6-chlorotryptophan
SMILES C([C@H](NC(OC(C)(C)C)=O)C(O)=O)C=1C=2C(NC1)=CC(Cl)=CC2

Computational Chemistry Data

TPSA 91.42
LogP 3.3417
H_Acceptors 3
H_Donors 3
Rotatable_Bonds 4

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Tryptophan and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Boc-Trp(6-Cl)-OH

CAS No. 1234875-52-5

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