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2-Boc-2-Azaspiro[3.3]heptane-6-methanesulfonate

  • CAS No. 1239320-11-6

  • Cat. No. CS-W023119
  • Molecule weight291.36
  • Purity≥97%
  • MDL No.MFCD29085851

*For research and further manufacturing use only, not for direct human use.

2-Boc-2-Azaspiro[3.3]heptane-6-methanesulfonate|CS-W023119

Structure of 1239320-11-6

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General Information

  • CAS No. 1239320-11-6
  • Cat. No. CS-W023119
  • Purity ≥97%
  • MDL No. MFCD29085851
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₅S
  • Molecular Weight 291.36
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CC2(C1)CC(OS(=O)(=O)C)C2

Description

tert-Butyl 6-((methylsulfonyl)oxy)-2-azaspiro[3.3]heptane-2-carboxylate features a spirocyclic azabicyclic core with a methylsulfonyl ether handle, enabling selective transformations in complex molecular scaffolds. The tert-butyl ester group provides stability and convenient deprotection under mild acidic conditions, while the sulfonyloxy moiety serves as an effective leaving group in nucleophilic substitution reactions. This compound integrates seamlessly into medicinal chemistry campaigns requiring robust, stereochemically defined building blocks.

Application

tert-Butyl 6-((methylsulfonyl)oxy)-2-azaspiro[3.3]heptane-2-carboxylate serves as a versatile spirocyclic building block for medicinal chemistry, enabling efficient access to constrained azaspiro[3.3]heptane scaffolds. The methylsulfonyloxy group facilitates nucleophilic substitution under mild conditions, while the tert-butyl ester provides stability and convenient deprotection. Its functional group tolerance supports downstream transformations in complex molecule synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   72.91
  • LogP   1.3621
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   2

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