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CS-W001157 4
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5-Bromo-7-(trifluoromethyl)quinoline

  • CAS No. 1239462-77-1

  • Cat. No. CS-0443217
  • Molecule weight276.05
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-7-(trifluoromethyl)quinoline|CS-0443217

Structure of 1239462-77-1

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General Information

  • CAS No. 1239462-77-1
  • Cat. No. CS-0443217
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₅BrF₃N
  • Molecular Weight 276.05
  • Synonym(s) None
  • SMILES C1=CC2=C(C=C(C=C2N=C1)C(F)(F)F)Br

Description

5-Bromo-7-(trifluoromethyl)quinoline features a sterically hindered trifluoromethyl group at the 7-position, enhancing metabolic stability and electron-withdrawing character. This quinoline scaffold integrates seamlessly into transition metal-catalyzed cross-coupling reactions, enabling efficient access to complex heterocyclic architectures in medicinal chemistry and materials science.

Application

5-Bromo-7-(trifluoromethyl)quinoline serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its well-defined reactivity at the bromo position. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the quinoline core provides a rigid, planar scaffold suitable for targeted molecular design. Bench-stable and compatible with standard purification protocols, it facilitates efficient synthesis of complex heterocyclic architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   4.0161
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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