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Structure of 1240113-42-1
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4-Fluoro-1H-indole-5-carbonitrile integrates a fluorinated indole core with a nitrile group at the 5-position, enabling direct functionalization in medicinal chemistry. This electron-deficient heterocycle features enhanced metabolic stability and favorable binding affinity for target proteins. The molecule’s planar structure facilitates π-stacking interactions, while its moisture-tolerant handling simplifies use in multistep synthesis workflows.
4-Fluoro-1H-indole-5-carbonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted indole scaffolds through standard coupling and functionalization reactions. The electron-withdrawing nitrile group enhances reactivity at the C5 position, while the fluorine substituent provides favorable metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with palladium-catalyzed cross-couplings facilitate rapid diversification in API lead development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Lot numbers can be found on the outside label of a product: