(2R,5R)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate

Name: (2R,5R)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1240586-48-4
Cat. No. CS-W021071
Purity≥95%
MDL No.MFCD08686669

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(2R,5R)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate|CS-W021071

Structure of 1240586-48-4

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Description

This bench-stable piperazine derivative features a tert-butyl ester group and two methyl substituents at the 2- and 5-positions, enabling straightforward functionalization. The stereochemistry at the 2R,5R centers provides defined spatial orientation for asymmetric synthesis applications. It integrates readily into medicinal chemistry campaigns requiring rigid, electron-rich heterocyclic scaffolds with enhanced solubility and metabolic stability.

Application

(2R,5R)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate serves as a stereochemically defined piperazine scaffold for medicinal chemistry applications. Its tert-butyl ester group enables straightforward deprotection under mild acidic conditions, while the methyl substituents provide enhanced metabolic stability and steric control. The compound exhibits excellent bench stability and functional group tolerance, facilitating its use in diverse coupling reactions and heterocycle construction workflows.

General Information

CAS No. 1240586-48-4
Cat. No. CS-W021071
Purity ≥95%
MDL No. MFCD08686669
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₂N₂O₂
Molecular Weight 214.31
Synonym(s) (2R,5R)-2,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester
SMILES C[C@@H]1CN([C@H](C)CN1)C(=O)OC(C)(C)C

Computational Chemistry Data

TPSA 41.57
LogP 1.6037
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(2R,5R)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate

CAS No. 1240586-48-4

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