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Structure of 1242157-23-8
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4-Bromo-2-fluoro-6-methylbenzoic acid features a trifunctional aromatic core with bromo, fluoro, and methyl substituents positioned for orthogonal reactivity. This electron-deficient platform enables direct coupling in cross-coupling reactions and serves as a key building block in medicinal chemistry. The carboxylic acid group facilitates derivatization under standard conditions, while the ortho-fluoro and para-bromo groups enable selective functionalization.
4-Bromo-2-fluoro-6-methylbenzoic acid serves as a versatile building block for pharmaceutical and agrochemical synthesis, enabling direct incorporation of halogenated aromatic motifs. Its orthogonal reactivity profile—combining bromine for cross-coupling and fluorine for metabolic stability—facilitates late-stage functionalization. The methyl group enhances lipophilicity and provides a site for oxidation or further derivatization. Bench-stable and readily purified by recrystallization, it functions effectively in Suzuki, Stille, and Negishi coupling protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: