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Structure of 1242446-32-7
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Methyl 8-bromoquinoline-2-carboxylate is a brominated quinoline ester featuring a strategically positioned bromine at the 8-position and a methyl carboxylate group at C2. This configuration enables direct functionalization in cross-coupling reactions, serving as a key intermediate in medicinal chemistry. The electron-deficient heterocyclic core enhances reactivity in Pd-catalyzed transformations, while the ester moiety offers tunable polarity for downstream derivatization.
Methyl 8-bromoquinoline-2-carboxylate serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. The bromine at the C8 position enables palladium-catalyzed cross-coupling reactions, while the quinoline core provides a rigid, planar scaffold with favorable pharmacophoric properties. The methyl ester group offers a handle for selective derivatization, including hydrolysis or reduction, facilitating downstream functionalization. Bench-stable and readily purified by column chromatography, it functions effectively in standard synthetic workflows involving nucleophilic substitution, metal-catalyzed coupling, and ring functionalization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362
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Lot numbers can be found on the outside label of a product: