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CS-W001157 4
Total: USD 88.00

5-Fluoro-6-methoxy-3-pyridinol

  • CAS No. 124432-71-9

  • Cat. No. CS-0647388
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-6-methoxy-3-pyridinol|CS-0647388

Structure of 124432-71-9

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General Information

  • CAS No. 124432-71-9
  • Cat. No. CS-0647388
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO₂
  • Molecular Weight 143.12
  • Synonym(s) None
  • SMILES OC1=CC(F)=C(OC)N=C1

Description

5-Fluoro-6-methoxy-3-pyridinol features a pyridinol core with strategically positioned fluorine and methoxy groups, delivering enhanced electron-withdrawing character and improved solubility. This combination enables efficient incorporation into bioactive scaffolds, particularly in kinase inhibitors and pharmaceutical intermediates, where metabolic stability and target affinity are critical.

Application

5-Fluoro-6-methoxy-3-pyridinol serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocyclic scaffolds. Its ortho-substituted pyridinol core offers enhanced metabolic stability and tunable polarity, while the methoxy group facilitates further functionalization via Suzuki-Miyaura or Ullmann coupling. The molecule exhibits excellent bench stability and compatibility with standard synthetic protocols, making it well-suited for iterative library synthesis and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   42.35
  • LogP   0.9349
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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