2-Chloro-5-methoxy-4-methylpyrimidine

Name: 2-Chloro-5-methoxy-4-methylpyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1245506-61-9
Cat. No. CS-0036515
Purity≥98%
MDL No.MFCD22394135

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-methoxy-4-methylpyrimidine|CS-0036515

Structure of 1245506-61-9

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Description

2-Chloro-5-methoxy-4-methylpyrimidine is a bench-stable, electron-deficient pyrimidine derivative featuring orthogonal functional groups enabling selective derivatization. The chloro substituent at C2 facilitates nucleophilic substitution, while the methoxy and methyl groups at C5 and C4, respectively, provide steric and electronic modulation. This compound serves as a key intermediate in the synthesis of bioactive heterocycles and agrochemical scaffolds.

Application

2-Chloro-5-methoxy-4-methylpyrimidine serves as a versatile pyrimidine scaffold for medicinal chemistry and agrochemical synthesis, enabling efficient functionalization via nucleophilic substitution at the C2 position. Its methoxy and methyl groups provide orthogonal reactivity and enhanced solubility, while the chlorine facilitates coupling with amines, thiols, and heterocycles under mild conditions. Bench-stable and readily purified by column chromatography, it functions as a key building block in the construction of bioactive heterocyclic frameworks.

General Information

CAS No. 1245506-61-9
Cat. No. CS-0036515
Purity ≥98%
MDL No. MFCD22394135
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂O
Molecular Weight 158.59
Synonym(s) None
SMILES CC1=NC(Cl)=NC=C1OC

Computational Chemistry Data

TPSA 35.01
LogP 1.44702
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-5-methoxy-4-methylpyrimidine

CAS No. 1245506-61-9

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