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CS-W001157 4
Total: USD 88.00

Pleuromutilin

  • CAS No. 125-65-5

  • Cat. No. CS-5813
  • Purity≥98%
  • MDL No.MFCD01939630
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Pleuromutilin|CS-5813

Structure of 125-65-5

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Description

A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 M in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 M, but at higher concentration (~100 M) it reversibly reduces K+ currents.

Application

Pleuromutilin serves as a privileged scaffold in medicinal chemistry, offering a rigid tetracyclic core with defined stereochemistry that enables selective functionalization at C14 and C2 positions. Its structural stability and low metabolic liability make it a valuable building block for antibacterial and antiviral lead optimization. The molecule facilitates direct derivatization via nucleophilic substitution or transition-metal-catalyzed coupling, supporting efficient synthesis of complex analogs with enhanced pharmacokinetic profiles.

General Information

  • CAS No. 125-65-5
  • Cat. No. CS-5813
  • Purity ≥98%
  • MDL No. MFCD01939630
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₃₄O₅
  • Molecular Weight 378.50
  • Synonym(s) Drosophilin B; Mutilin 14-glycolate
  • SMILES C[C@@H]([C@@H]([C@@](C)(C[C@H]1OC(CO)=O)C=C)O)C(CC[C@H]2C)(CCC3=O)[C@]3([H])C21C

Computational Chemistry Data

  • TPSA   83.83
  • LogP   2.8852
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H410
Precautionary Statements : P264-P270-P273-P330-P391-P501

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