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Structure of 125110-82-9
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4,4-Difluoropentanoic acid features a geminal difluoro substitution at the C4 position, imparting enhanced metabolic stability and altered lipophilicity. This structural motif enables strategic incorporation into bioactive molecules, particularly as a metabolically resistant isostere of common alkyl chains. The carboxylic acid functionality supports direct derivatization or salt formation for improved solubility and handling.
4,4-Difluoropentanoic acid serves as a valuable building block in medicinal chemistry, enabling the introduction of a sterically constrained, electron-withdrawing difluoromethyl group adjacent to a carboxylic acid. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient incorporation into bioactive molecules. The molecule functions as a versatile synthon for fluorinated aliphatic motifs found in pharmaceutical scaffolds, offering enhanced metabolic stability and modulated lipophilicity.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: