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Structure of 1251459-71-8
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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isothiazole integrates a boronate ester moiety with an electron-deficient isothiazole ring, enabling direct coupling in palladium-catalyzed cross-coupling reactions. This bench-stable reagent delivers efficient access to diverse heteroaryl architectures under standard conditions.
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isothiazole serves as a stable, bench-friendly boronate building block for Suzuki-Miyaura coupling reactions. Its isothiazole core provides orthogonal reactivity and enhances metabolic stability in medicinal chemistry applications. The tetramethyl-substituted dioxaborolane moiety ensures high functional group tolerance, minimal protodeboronation, and compatibility with diverse reaction conditions. This compound enables efficient construction of biaryl and heteroaryl scaffolds in drug discovery and materials science workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: