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Structure of 1255666-39-7
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tert-Butyl 5,5-difluoro-2-(hydroxymethyl)piperidine-1-carboxylate features a sterically hindered piperidine core with dual fluorine atoms at the 5-position, enhancing metabolic stability. The pendant hydroxymethyl group enables direct functionalization or derivatization in synthetic routes. This bench-stable, moisture-tolerant building block integrates readily into complex molecular architectures requiring fluorinated heterocyclic motifs.
tert-Butyl 5,5-difluoro-2-(hydroxymethyl)piperidine-1-carboxylate serves as a versatile building block for fluorinated piperidine scaffolds in medicinal chemistry. The difluoro substitution at the C5 position imparts enhanced metabolic stability and modulates basicity, while the hydroxymethyl group enables downstream functionalization via oxidation, reduction, or coupling reactions. The tert-butyl carbamate protects the nitrogen during synthesis, offering excellent bench stability and straightforward deprotection under mild acidic conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: