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CS-W001157 4
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(4-Cyano-2-methoxyphenyl)boronic acid

  • CAS No. 1256345-67-1

  • Cat. No. CS-W006766
  • Purity≥95%
  • MDL No.MFCD16618929

*For research and further manufacturing use only, not for direct human use.

(4-Cyano-2-methoxyphenyl)boronic acid|CS-W006766

Structure of 1256345-67-1

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General Information

  • CAS No. 1256345-67-1
  • Cat. No. CS-W006766
  • Purity ≥95%
  • MDL No. MFCD16618929
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BNO₃
  • Molecular Weight 176.97
  • Synonym(s) 4-Cyano-2-methoxyphenylboronic acid
  • SMILES COC1=C(C=CC(=C1)C#N)B(O)O

Description

This boronate moiety features a cyano group at the para position and a methoxy substituent ortho to the boronic acid, enhancing electronic stabilization and solubility. The electron-deficient aryl core enables efficient Suzuki-Miyaura cross-coupling under standard conditions, while the bench-stable boronate ester offers reliable performance in synthetic workflows.

Application

(4-Cyano-2-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. Its cyano and methoxy groups provide orthogonal reactivity and enhanced solubility, while the boronic acid moiety offers excellent bench stability and ease of purification. Widely used in the synthesis of functionalized aryl scaffolds for pharmaceutical and materials applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   73.48
  • LogP   -0.75332
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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