Methyl 5-bromo-6-chloro-2-methylnicotinate

Name: Methyl 5-bromo-6-chloro-2-methylnicotinate
Brand: ChemScene
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CAS No. 1256788-63-2
Cat. No. CS-0568355
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Methyl 5-bromo-6-chloro-2-methylnicotinate|CS-0568355

Structure of 1256788-63-2

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Description

Methyl 5-bromo-6-chloro-2-methylnicotinate features a densely functionalized pyridine core with orthogonal halogen handles at C5 (bromo) and C6 (chloro), enabling selective cross-coupling. The methyl group at C2 enhances solubility and modulates electronic properties, while the ester moiety provides a handle for downstream transformations. This compound serves as a key building block in synthetic routes to bioactive heterocycles and pharmaceutical intermediates.

Application

Methyl 5-bromo-6-chloro-2-methylnicotinate serves as a versatile building block in heterocyclic synthesis, enabling regioselective functionalization at the C5 and C6 positions. The bromo and chloro substituents facilitate palladium-catalyzed cross-coupling reactions, while the methyl ester group supports further transformations such as hydrolysis or reduction. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for medicinal chemistry and process development workflows.

General Information

CAS No. 1256788-63-2
Cat. No. CS-0568355
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇BrClNO₂
Molecular Weight 264.50
Synonym(s) 3-Pyridinecarboxylic acid, 5-broMo-6-chloro-2-Methyl-, Methyl ester
SMILES O=C(C1=CC(Br)=C(Cl)N=C1C)OC

Computational Chemistry Data

TPSA 39.19
LogP 2.59252
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Methyl 5-bromo-6-chloro-2-methylnicotinate

CAS No. 1256788-63-2

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