2-Bromo-6-methoxy-4-methylpyridine

Name: 2-Bromo-6-methoxy-4-methylpyridine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1256807-52-9
Cat. No. CS-0196628
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Bromo-6-methoxy-4-methylpyridine|CS-0196628

Structure of 1256807-52-9

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Description

2-Bromo-6-methoxy-4-methylpyridine features a strategically positioned bromine atom enabling direct functionalization in cross-coupling reactions. The methoxy and methyl groups enhance electron density at the pyridine ring, improving reactivity while maintaining stability under standard conditions. This scaffold serves as a key building block for pharmaceutical intermediates and functionalized heterocycles.

Application

2-Bromo-6-methoxy-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined regiochemistry and stability under standard reaction conditions. The bromo group facilitates efficient C–C bond formation, while the methoxy and methyl substituents provide predictable electronic modulation and steric control. This compound functions reliably in the synthesis of functionalized pyridine scaffolds commonly found in pharmaceutical intermediates.

General Information

CAS No. 1256807-52-9
Cat. No. CS-0196628
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈BrNO
Molecular Weight 202.05
Synonym(s) None
SMILES CC1=CC(Br)=NC(OC)=C1

Computational Chemistry Data

TPSA 22.12
LogP 2.16112
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Bromo-6-methoxy-4-methylpyridine

CAS No. 1256807-52-9

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