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Structure of 1260024-26-7
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2-Bromo-3-methylisonicotinonitrile features a strategically positioned bromine atom and nitrile group on a methyl-substituted pyridine core, enabling direct functionalization in cross-coupling reactions. The electron-deficient heterocycle facilitates palladium-catalyzed transformations, while the methyl group enhances solubility and modulates reactivity. This compound serves as a key intermediate for bioactive heterocycles and advanced synthetic scaffolds.
2-Bromo-3-methylisonicotinonitrile serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to construct substituted pyridine scaffolds. Its bromo group facilitates C–C bond formation under standard Suzuki, Stille, or Negishi conditions, while the nitrile and methyl functionalities provide orthogonal reactivity for downstream derivatization. The compound exhibits good bench stability and is amenable to purification via flash chromatography, supporting its utility in multi-step synthesis campaigns.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: