Fmoc-3-methoxy-L-homophenylalanine

Name: Fmoc-3-methoxy-L-homophenylalanine
Brand: ChemScene
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CAS No. 1260610-23-8
Cat. No. CS-0188069
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Fmoc-3-methoxy-L-homophenylalanine|CS-0188069

Structure of 1260610-23-8

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Description

Fmoc-3-methoxy-L-homophenylalanine integrates a methoxy-substituted aromatic ring with a robust Fmoc protecting group, enabling efficient solid-phase peptide synthesis. The electron-donating methoxy moiety enhances solubility and modulates backbone conformation, while the homophenylalanine scaffold provides steric bulk and hydrophobic character for targeted protein interactions.

Application

Fmoc-3-methoxy-L-homophenylalanine serves as a valuable building block in peptide synthesis, enabling the incorporation of a methoxy-substituted aromatic side chain. The Fmoc group provides orthogonal protection for the α-amino function, facilitating efficient solid-phase peptide coupling. The 3-methoxyphenylalanine moiety offers enhanced lipophilicity and metabolic stability, making it useful in the design of bioactive peptides and peptidomimetics. This derivative exhibits excellent bench stability and compatibility with standard purification protocols.

General Information

CAS No. 1260610-23-8
Cat. No. CS-0188069
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₆H₂₅NO₅
Molecular Weight 431.48
Synonym(s) None
SMILES C(OC(N[C@@H](CCC1=CC(OC)=CC=C1)C(O)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3

Computational Chemistry Data

TPSA 84.86
LogP 4.6197
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 8

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-3-methoxy-L-homophenylalanine

CAS No. 1260610-23-8

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