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CS-W001157 4
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Fmoc-3-methoxy-L-homophenylalanine

  • CAS No. 1260610-23-8

  • Cat. No. CS-0188069
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Fmoc-3-methoxy-L-homophenylalanine|CS-0188069

Structure of 1260610-23-8

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General Information

  • CAS No. 1260610-23-8
  • Cat. No. CS-0188069
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₆H₂₅NO₅
  • Molecular Weight 431.48
  • Synonym(s) None
  • SMILES C(OC(N[C@@H](CCC1=CC(OC)=CC=C1)C(O)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3

Description

Fmoc-3-methoxy-L-homophenylalanine integrates a methoxy-substituted aromatic ring with a robust Fmoc protecting group, enabling efficient solid-phase peptide synthesis. The electron-donating methoxy moiety enhances solubility and modulates backbone conformation, while the homophenylalanine scaffold provides steric bulk and hydrophobic character for targeted protein interactions.

Application

Fmoc-3-methoxy-L-homophenylalanine serves as a valuable building block in peptide synthesis, enabling the incorporation of a methoxy-substituted aromatic side chain. The Fmoc group provides orthogonal protection for the α-amino function, facilitating efficient solid-phase peptide coupling. The 3-methoxyphenylalanine moiety offers enhanced lipophilicity and metabolic stability, making it useful in the design of bioactive peptides and peptidomimetics. This derivative exhibits excellent bench stability and compatibility with standard purification protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   84.86
  • LogP   4.6197
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   8

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