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6-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine

  • CAS No. 1260667-73-9

  • Cat. No. CS-0169580
  • Molecule weight232.47
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine|CS-0169580

Structure of 1260667-73-9

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General Information

  • CAS No. 1260667-73-9
  • Cat. No. CS-0169580
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClN₃
  • Molecular Weight 232.47
  • Synonym(s) None
  • SMILES ClC1=NN2C=C(Br)C=CC2=N1

Description

6-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine features a fused triazolopyridine core bearing bromo and chloro substituents at the 6- and 2-positions, respectively. This electron-deficient heterocycle enables efficient coupling reactions in C–H functionalization and transition-metal-catalyzed cross-coupling processes. The strategic halogen placement supports sequential derivatization, facilitating rapid access to complex nitrogen-rich scaffolds for medicinal chemistry and materials applications.

Application

6-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine serves as a versatile heterocyclic building block in medicinal chemistry and materials science. Its dual halogenation pattern enables sequential cross-coupling reactions, facilitating the construction of complex molecular architectures. The molecule exhibits excellent bench stability and compatibility with palladium-catalyzed transformations, making it well-suited for iterative synthesis workflows. Functional group tolerance supports its use in late-stage diversification strategies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   2.1452
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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