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5,6,7,8-Tetrahydro-2-(trifluoromethyl)imidazo[1,2-a]pyrazine

  • CAS No. 126069-70-3

  • Cat. No. CS-0018906
  • Molecule weight191.15
  • Purity≥96%
  • MDL No.MFCD09834983

*For research and further manufacturing use only, not for direct human use.

5,6,7,8-Tetrahydro-2-(trifluoromethyl)imidazo[1,2-a]pyrazine|CS-0018906

Structure of 126069-70-3

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General Information

  • CAS No. 126069-70-3
  • Cat. No. CS-0018906
  • Purity ≥96%
  • MDL No. MFCD09834983
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈F₃N₃
  • Molecular Weight 191.15
  • Synonym(s) 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
  • SMILES FC(C1=CN2C(CNCC2)=N1)(F)F

Description

5,6,7,8-Tetrahydro-2-(trifluoromethyl)imidazo[1,2-a]pyrazine is a heterocyclic scaffold featuring a trifluoromethyl group that imparts enhanced metabolic stability and lipophilicity. This electron-deficient core integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds. The saturated imidazopyrazine framework ensures improved solubility and reduced aromaticity compared to fully conjugated analogs.

Application

5,6,7,8-Tetrahydro-2-(trifluoromethyl)imidazo[1,2-a]pyrazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling access to bioactive scaffolds through standard functionalization protocols. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the saturated imidazopyrazine core provides a rigid, electron-deficient platform for transition metal-catalyzed couplings and nucleophilic substitutions. The compound exhibits excellent bench stability and compatibility with common purification methods, facilitating integration into multi-step syntheses of pharmaceutical candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H318
Precautionary Statements : P264-P270-P280-P330-P405-P501

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Computational Chemistry Data

  • TPSA   29.85
  • LogP   1.0051
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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