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CS-W001157 4
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7-Chloroquinoline-8-carbaldehyde

  • CAS No. 1260759-71-4

  • Cat. No. CS-0488759
  • Purity≥98%
  • MDL No.MFCD15526827

*For research and further manufacturing use only, not for direct human use.

7-Chloroquinoline-8-carbaldehyde|CS-0488759

Structure of 1260759-71-4

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General Information

  • CAS No. 1260759-71-4
  • Cat. No. CS-0488759
  • Purity ≥98%
  • MDL No. MFCD15526827
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆ClNO
  • Molecular Weight 191.61
  • Synonym(s) None
  • SMILES ClC1=C(C=O)C2=C(C=CC=N2)C=C1

Description

7-Chloroquinoline-8-carbaldehyde delivers a potent electrophilic aldehyde handle fused to an electron-deficient quinoline scaffold. This rigid, heteroaromatic platform enables direct integration into bioactive molecule architectures, particularly in medicinal chemistry campaigns targeting kinase inhibition and antiparasitic agents. The aldehyde group facilitates efficient condensation reactions under mild conditions.

Application

7-Chloroquinoline-8-carbaldehyde serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electrophilic aldehyde functionality enables efficient coupling reactions, including reductive amination and Grignard additions, while the quinoline scaffold offers enhanced π-stacking and metabolic stability. Bench-stable and compatible with standard purification methods, it facilitates scalable access to advanced scaffolds in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.7007
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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